Trending...
- MahoganyBooks Celebrates 2nd Annual Black Books Matter Day
- Arch Amenities Group Acquires Pool Management and Construction Company
- Maryland Tech Council Seeks Technologies that Enable Diversity, Equity, and Inclusivity Strategies in the Workplace
Prestigious CDMRP award will advance development of ORP100S as an inhaled treatment for acute and chronic respiratory diseases
SAN DIEGO - Marylandian -- OrPro Therapeutics, Inc., a San Diego Johnson & Johnson JLABS alumni and 2022 SD CONNECT Cool Company, is pleased to announce that it has been awarded a Fiscal Year 2021 (FY21) Peer Reviewed Medical Research Program (PRMRP) Technology/Therapeutic Development grant under the Congressionally Directed Medical Research Program (CDMRP) of the US Department of Defense. This $2.147M award entitled "Development of Monothiol Human Thioredoxin-1 (ORP100S) as an Inhaled Treatment for Acute Viral Lung Injury" involves OrPro researchers and collaborators at the Institute for Airway Sciences in the Icahn School of Medicine at Mount Sinai (New York, NY), Lovelace Biomedical (Albuquerque, NM), and KCAS Bioanalytical Services (Olathe, KS). Project advisors include innate immunity opinion leader Dr. Richard Ulevitch, Professor and former Chair of the Department of Immunology at Scripps Research; 3-D stem cell derived human lung organoid pioneer Dr. Ya-Wen Chen at Mount Sinai; and internationally recognized inhalation toxicology expert Dr. Jeffrey Tepper.
The objective of the grant-funded research is to understand the pharmacodynamic effect of ORP100S in vitro and in vivo for treatment of relevant viral diseases (COVID-19 and influenza), as well as to establish a validated bioanalytical method for the detection and quantification of ORP100S in plasma/serum and lung matrices from humans and non-clinical toxicology species. These objectives represent key ORP100S development milestones toward a US FDA Investigational New Drug (IND) filing and human clinical trials.
More on Marylandian
"CDMRP funding is highly competitive. Our team is tremendously excited to be recognized by the Department of Defense for the potential of our drug platform to impact respiratory health by filling a critical gap in the prevention of lung injury associated with viral infection and inflammation," said Dr. Peter Heifetz, Founder, President and CEO of OrPro Therapeutics. "This award will enable us to rapidly advance ORP100S for multiple indications with high unmet medical need."
"Our 3-D human lung organoid system has been proven to accurately recapitulate respiratory viral infection and host responses, making it ideal for evaluation of the efficacy and mechanism of novel therapeutics. I am looking forward to working with Principal Investigator Dr. Heifetz and the project team to combine our in vitro human system with parallel in vivo studies in relevant animal infection models, said Dr. Ya-Wen Chen, Assistant Professor, Icahn School of Medicine at Mount Sinai. "This dual approach has great promise for enabling successful translation to clinical studies."
Thioredoxin
Secreted human thioredoxin (TRX) is a target-selective thiol-disulfide exchange enzyme that acts homeostatically to modulate inflammatory cytokine release, oxidative stress, and abnormal airway mucus viscoelasticity via regulatory interaction with extracellular cell-surface protein disulfides. TRX lowers inflammation in acute lung injury, and published studies show it can prevent viral pneumonia and increase survival in influenza-infected animal models. OrPro has developed the proprietary Theradux® platform of TRX derivatives optimized for extracellular delivery and function with increased half-life and decreased potential for intracellular uptake and off-target activity. Lead development candidate ORP100S is highly active extracellularly as a cell protectant without promoting cellular proliferation and is being advanced as an inhaled nebulized solution for treatment of acute and chronic obstructive/inflammatory airway diseases.
More on Marylandian
About OrPro Therapeutics
OrPro Therapeutics, Inc is a privately held preclinical-stage company pioneering a novel biologic drug platform for treating severe respiratory, ophthalmic, and mucosal diseases. The company's differentiated approach targets both lung clearance and inflammation as well as obstructive/inflammatory disorders associated with non-respiratory mucosal surfaces in the body. Launched in 2013 with technology in-licensed from National Jewish Health, the leading US respiratory research center, the company has secured Series A financing and significant non-dilutive grant funding from the National Institutes of Health and the Cystic Fibrosis Foundation with over $7M raised to date. For more information visit www.orprotherapeutics.com.
Contact
Peter Heifetz, Ph.D. OrPro Therapeutics, Inc. pheifetz@orprotherapeutics.com;
Media: Joleen Schultz, joleen@joleenschultzassociates.com; 760-271-8150
The objective of the grant-funded research is to understand the pharmacodynamic effect of ORP100S in vitro and in vivo for treatment of relevant viral diseases (COVID-19 and influenza), as well as to establish a validated bioanalytical method for the detection and quantification of ORP100S in plasma/serum and lung matrices from humans and non-clinical toxicology species. These objectives represent key ORP100S development milestones toward a US FDA Investigational New Drug (IND) filing and human clinical trials.
More on Marylandian
- Kinugawa Onsen Celebrates its 330th Anniversary AND Kawagoe City Celebrates its 100th Anniversary - Both with Fireworks!
- Anirban Basu Presents Economic Update for The Prosperity Consulting Group
- Celebrate Maryland Farmers' Market Week August 7-13
- VA Center of North County Hosts It's First Annual VANC Fest; an Art, Music and Culinary Experience
- 10 Years in the Making: #LatinaGeeks Celebrates 10th Anniversary with Inaugural Inspirada Awards & Fundraising Gala
"CDMRP funding is highly competitive. Our team is tremendously excited to be recognized by the Department of Defense for the potential of our drug platform to impact respiratory health by filling a critical gap in the prevention of lung injury associated with viral infection and inflammation," said Dr. Peter Heifetz, Founder, President and CEO of OrPro Therapeutics. "This award will enable us to rapidly advance ORP100S for multiple indications with high unmet medical need."
"Our 3-D human lung organoid system has been proven to accurately recapitulate respiratory viral infection and host responses, making it ideal for evaluation of the efficacy and mechanism of novel therapeutics. I am looking forward to working with Principal Investigator Dr. Heifetz and the project team to combine our in vitro human system with parallel in vivo studies in relevant animal infection models, said Dr. Ya-Wen Chen, Assistant Professor, Icahn School of Medicine at Mount Sinai. "This dual approach has great promise for enabling successful translation to clinical studies."
Thioredoxin
Secreted human thioredoxin (TRX) is a target-selective thiol-disulfide exchange enzyme that acts homeostatically to modulate inflammatory cytokine release, oxidative stress, and abnormal airway mucus viscoelasticity via regulatory interaction with extracellular cell-surface protein disulfides. TRX lowers inflammation in acute lung injury, and published studies show it can prevent viral pneumonia and increase survival in influenza-infected animal models. OrPro has developed the proprietary Theradux® platform of TRX derivatives optimized for extracellular delivery and function with increased half-life and decreased potential for intracellular uptake and off-target activity. Lead development candidate ORP100S is highly active extracellularly as a cell protectant without promoting cellular proliferation and is being advanced as an inhaled nebulized solution for treatment of acute and chronic obstructive/inflammatory airway diseases.
More on Marylandian
- Downtown Brooklyn Gains A Mixed-Use Gem with The Brook, Financing Arranged by Walker & Dunlop
- 3i Solutions Announces New Leadership Brings a Customer-Focused Approach
- MahoganyBooks Celebrates 2nd Annual Black Books Matter Day
- Barcoding, Inc. Named a 2022 Great Supply Chain Partner
- Loving Cook Nook: Perfect Your Cooking Skills With The Proper Tools And Utensils
About OrPro Therapeutics
OrPro Therapeutics, Inc is a privately held preclinical-stage company pioneering a novel biologic drug platform for treating severe respiratory, ophthalmic, and mucosal diseases. The company's differentiated approach targets both lung clearance and inflammation as well as obstructive/inflammatory disorders associated with non-respiratory mucosal surfaces in the body. Launched in 2013 with technology in-licensed from National Jewish Health, the leading US respiratory research center, the company has secured Series A financing and significant non-dilutive grant funding from the National Institutes of Health and the Cystic Fibrosis Foundation with over $7M raised to date. For more information visit www.orprotherapeutics.com.
Contact
Peter Heifetz, Ph.D. OrPro Therapeutics, Inc. pheifetz@orprotherapeutics.com;
Media: Joleen Schultz, joleen@joleenschultzassociates.com; 760-271-8150
Source: OrPro Therapeutics
Filed Under: Government
0 Comments
Latest on Marylandian
- Maryland Horse Industry Board Accepting 2023 Grant Applications
- Century 21's The Gene Group Joins PalMar Studios as a Primary Partner on "Triangle Park," a Documentary on the NFL's First-Ever Game
- Inferno Phil's Outpost Introduces the Ice-Pron,The High-Tech BBQ Apron Along with Craft Hot Sauces
- Women of Color STEM Conference Announces 2022 List of Award Recipients
- Dr. Valerie Sheares Ashby is 2022 Women of Color Technologist of the Year
- Prince Oak Oakleyski has finished directing and already released his new film, the final episode of "Prince Oakleyski Is Enough". A non-profit movie
- Sinclair Announces Agreements with Korean Broadcasters to Further NextGen Broadcasting
- Precigen to Announce Second Quarter and First Half 2022 Financial Results on August 8th
- 3C Group to Distribute Certified Nutraceuticals' Functional Ingredients for Dietary Supplements in Thailand
- Maryland: MDA Secretary Bartenfelder Opens 2022 International Leadership Alumni Conference
- Calling All Witches: WitchFest 2022 Announced in Denver Colorado
- Maryland Tech Council Seeks Technologies that Enable Diversity, Equity, and Inclusivity Strategies in the Workplace
- Maryland: MDA Now Accepting Applications for Governor's Ag Hall of Fame
- Arch Amenities Group Acquires Pool Management and Construction Company
- New music from Sho Richardsin, 'The Win'
- JBG SMITH Declares a Quarterly Common Dividend of $0.225 Per Share
- Fashion Umbrella Foundation Prepares for 4th Annual Gala and Impact Awards
- Sharifah Hardie Launches Campaign to Raise $1.5B for Local Black Businesses
- Continuing To Champion Change for Mental Health Awareness and Suicide Prevention
- COPT Executes Build-to-Suit Lease with Defense Contractor at The National Business Park